Reactome | NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP

NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP

Stable Identifier

R-HSA-9748969

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

6TdGDP--DPK-->6TdGTP

ReviewStatus

5/5

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NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP

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6-thioguanine nucleotides (6-TGNs) consist of 6-thio(dexoy)guanosine 5'-monophosphate (T(d)GMP), -diphosphate (T(d)GDP), and -triphosphate (T(d)GTP), representing the pharmacologically-active metabolites involved in drug action of thiopurines.

Nucleoside diphosphate kinase (NME) plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 forms a hexameric complex with NME2 and this complex is thought to phosphorylate 6-thiodeoxyguanosine diphosphate (6TdGDP) to 6-thiodeoxyguanosine triphosphate (6TdGTP) (Karner et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20216118	Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy? Hofmann, U, Karner, S, Schwab, M, Schaeffeler, E, Fischer, C, Herrlinger, KR, Shi, S, Neurath, MF	Ther Drug Monit	2010