p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter

Stable Identifier
R-HSA-9736979
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SMAD2/3:SMAD4:SP1 complex binds SP1 and SMAD promoter elements of CDKN2B (p15-INK4B) gene and stimulates transcription of CDKN2B (Feng et al. 2000).

Literature References
PubMed ID Title Journal Year
11013220 Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

Feng, XH, Lin, X, Derynck, R

EMBO J 2000
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