SMAD7 binds SERPINE1 gene promoter

Stable Identifier
R-HSA-9736966
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SMAD7 can bind the SERPINE1 (PAI-1) gene promoter (and probably other TGF-beta-responsive promoters) and inhibit PAI-1 expression by competing with SMAD2,3:SMAD4 binding (Zhang et al. 2007).

Literature References
PubMed ID Title Journal Year
17438144 Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation

Zhang, S, Fei, T, Zhang, L, Zhang, R, Chen, F, Ning, Y, Han, Y, Feng, XH, Meng, A, Chen, YG

Mol. Cell. Biol. 2007
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