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FURIN translocates to the plasma membrane
Stable Identifier
R-HSA-9736953
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Golgi membrane
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
FURIN translocates to the plasma membrane (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
FURIN translocates to the plasma membrane (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
While FURIN mainly localizes to the Golgi apparatus/trans-Golgi network sites (TGN), it also localizes to the plasma membrane and endosomes and cycles between these subcellular compartments (Mayer et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
15100235
Sorting of furin in polarized epithelial and endothelial cells: expression beyond the Golgi apparatus
Mayer, G
,
Bendayan, M
,
Boileau, G
J Histochem Cytochem
2004
Participants
Input
FURIN [Golgi membrane]
(Homo sapiens)
Output
FURIN [plasma membrane]
(Homo sapiens)
Participates
as an event of
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Orthologous Events
FURIN translocates to the plasma membrane (Bos taurus)
FURIN translocates to the plasma membrane (Caenorhabditis elegans)
FURIN translocates to the plasma membrane (Canis familiaris)
FURIN translocates to the plasma membrane (Danio rerio)
FURIN translocates to the plasma membrane (Drosophila melanogaster)
FURIN translocates to the plasma membrane (Gallus gallus)
FURIN translocates to the plasma membrane (Mus musculus)
FURIN translocates to the plasma membrane (Plasmodium falciparum)
FURIN translocates to the plasma membrane (Rattus norvegicus)
FURIN translocates to the plasma membrane (Saccharomyces cerevisiae)
FURIN translocates to the plasma membrane (Schizosaccharomyces pombe)
FURIN translocates to the plasma membrane (Sus scrofa)
FURIN translocates to the plasma membrane (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2021-07-15)
Reviewed
Contreras, O (2022-05-02)
Created
Orlic-Milacic, M (2021-07-15)
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