Reactome | Phosphorylated YBX1 translocates to the nucleus

Phosphorylated YBX1 translocates to the nucleus

Stable Identifier

R-HSA-9736836

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

3/5

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Phosphorylated YBX1 translocates to the nucleus

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Interferon-gamma (IFNG) signaling was shown to induce nuclear translocation of YBX1 and its binding to the promoter of the collagen I gene COL1A2 (Higashi et al. 2003). Based on studies in mice, phosphorylation of YBX1 on serine residues S32 and S36 (S30 and S34 in mouse Ybx1) by MAPK1 and/or MAPK3 (ERK2 and ERK1, respectively) is needed for the nuclear translocation of YBX1 and depends on JAK2, which may promote the interaction between YBX1 and ERKs (Jayavelu et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
33239784	Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms Schnöder, TM, Heidel, FH, Ernst, T, Bullinger, L, Mohr, J, Palandri, F, Jilg, S, Meiler, A, Brandt, S, Hübner, CA, Ungelenk, M, Huber, N, Herzog, C, Jayavelu, AK, Schröder, N, Rahmig, S, Jost, PJ, Sinha, AU, Austin, R, Isermann, B, Waskow, C, Edlich, F, Lane, SW, Krishnamoorthy, G, Mullally, A, Coldham, I, Zeiser, R, Edelmann-Stephan, B, Mann, M, Perner, F, Mertens, PR, Hochhaus, A	Nature	2020
12446674	Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma Mitsui, S, Higashi, K, Mauviel, A, Suzuki, N, Nakatsuka, I, Kaneko, H, Inagaki, Y	J Biol Chem	2003