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ORC2:ORC3 [nucleoplasm]
Stable Identifier
R-HSA-9735400
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Formation of ORC(1-5) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
Formation of ORC(1-6) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
Formation of ORC(2-5) complex (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2 binds ORC3 (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC5 binds ORC2:ORC3 (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
CDC6 association with the ORC:origin complex (Homo sapiens)
CDC6 association with ORC(1-6) at replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16549788
A structural role for ATP in the formation and stability of the human origin recognition complex
Gossen, M
,
Ranjan, A
Proc Natl Acad Sci U S A
2006
Participants
components
ORC2 [nucleoplasm]
(Homo sapiens)
ORC3 [nucleoplasm]
(Homo sapiens)
Participates
as an input of
ORC5 binds ORC2:ORC3 (Homo sapiens)
as an output of
ORC2 binds ORC3 (Homo sapiens)
as a component of
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
Inferred To
ORC2:ORC3 [nucleoplasm]
(Bos taurus)
ORC2:ORC3 [nucleoplasm]
(Caenorhabditis elegans)
ORC2:ORC3 [nucleoplasm]
(Canis familiaris)
ORC2:ORC3 [nucleoplasm]
(Dictyostelium discoideum)
ORC2:ORC3 [nucleoplasm]
(Drosophila melanogaster)
ORC2:ORC3 [nucleoplasm]
(Gallus gallus)
ORC2:ORC3 [nucleoplasm]
(Mus musculus)
ORC2:ORC3 [nucleoplasm]
(Rattus norvegicus)
ORC2:ORC3 [nucleoplasm]
(Saccharomyces cerevisiae)
ORC2:ORC3 [nucleoplasm]
(Schizosaccharomyces pombe)
ORC2:ORC3 [nucleoplasm]
(Sus scrofa)
ORC2:ORC3 [nucleoplasm]
(Xenopus tropicalis)
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