Expression of HAND1 in cardiogenesis

Stable Identifier
R-HSA-9735276
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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Expression of HAND1 in cardiogenesis
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The HAND1 (eHAND) gene is transcribed to yield mRNA and the mRNA is translated to yield HAND1 protein (Anderson et al. 2018). HAND1 is expressed in the left ventricle during cardiogenesis. NKX2-5 binds the HAND1 gene and activates transcription (Anderson et al. 2018). GATA4 also binds and activates HAND1 (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
29636455 NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Labonne, T, Stanley, EG, Haynes, JM, Kaplan, DI, Elefanty, AG, Arasaratnam, D, Costa, MW, Porrello, ER, Casini, S, Anderson, DJ, Leitoguinho, AR, Rafii, A, Qian, EL, Harvey, RP, Oshlack, A, Phelan, DG, Petrou, S, Hudson, JE, Cheung, MM, Mills, RJ, Delbridge, LM, Bell, KM, Mummery, CL, Curl, CL, Ng, ES, Elliott, DA, Davis, RP, Koutsis, K, Passier, R

Nat Commun 2018
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
GATA4:NKX2-5:HAND1 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Hand1 in cardiogenesis (Mus musculus)
Authored
May, B  (2021-06-23)
Created
May, B  (2021-06-24)
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