GATA4 and NKX2-5 bind the HAND1 gene

Stable Identifier
R-HSA-9735268
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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GATA4 and NKX2-5 bind the HAND1 gene
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NKX2-5 binds the HAND1 (eHAND) gene and activates transcription (Anderson et al. 2018). GATA4 binds two evolutionarily conserved sites in an upstream enhancer (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
29636455 NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Anderson, DJ, Kaplan, DI, Bell, KM, Koutsis, K, Haynes, JM, Mills, RJ, Phelan, DG, Qian, EL, Leitoguinho, AR, Arasaratnam, D, Labonne, T, Ng, ES, Davis, RP, Casini, S, Passier, R, Hudson, JE, Porrello, ER, Costa, MW, Rafii, A, Curl, CL, Delbridge, LM, Harvey, RP, Oshlack, A, Cheung, MM, Mummery, CL, Petrou, S, Elefanty, AG, Stanley, EG, Elliott, DA

Nat Commun 2018
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Output
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as an event of
Inferred From
Gata4 binds the Hand1 gene (Mus musculus)
Authored
May, B  (2021-06-23)
Created
May, B  (2021-06-24)
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