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ORC6 binds KPNA1 or KPNA6
Stable Identifier
R-HSA-9734670
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
ORC6 binds KPNA1 or KPNA6 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ORC6 binds to importin alpha family members KPNA1 and KPNA6, in complex with the importin beta (KPNB1). Phosphorylation of ORC6 at threonine residue 195 (T195) is not a pre-requisite for binding to KPNA1/KPNA6 although it does facilitate translocation of ORC6 to the nucleus (Ghosh et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
21555516
Assembly of the human origin recognition complex occurs through independent nuclear localization of its components
Ghosh, S
,
Zhao, Y
,
Vassilev, AP
,
Zhang, J
,
DePamphilis, ML
J Biol Chem
2011
Participants
Input
KPNA1,KPNA6:KPNB1 [cytosol]
(Homo sapiens)
ORC6 [cytosol]
(Homo sapiens)
Output
ORC6:KPNA1,KPNA6:KPNB1 [cytosol]
(Homo sapiens)
Participates
as an event of
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Orthologous Events
ORC6 binds KPNA1 or KPNA6 (Bos taurus)
ORC6 binds KPNA1 or KPNA6 (Canis familiaris)
ORC6 binds KPNA1 or KPNA6 (Drosophila melanogaster)
ORC6 binds KPNA1 or KPNA6 (Gallus gallus)
ORC6 binds KPNA1 or KPNA6 (Mus musculus)
ORC6 binds KPNA1 or KPNA6 (Rattus norvegicus)
ORC6 binds KPNA1 or KPNA6 (Schizosaccharomyces pombe)
ORC6 binds KPNA1 or KPNA6 (Sus scrofa)
ORC6 binds KPNA1 or KPNA6 (Xenopus tropicalis)
Authored
Kusic-Tisma, J (2021-06-18)
Created
Kusic-Tisma, J (2021-06-18)
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