ORC6 binds KPNA1 or KPNA6

Stable Identifier
R-HSA-9734670
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ORC6 binds to importin alpha family members KPNA1 and KPNA6, in complex with the importin beta (KPNB1). Phosphorylation of ORC6 at threonine residue 195 (T195) is not a pre-requisite for binding to KPNA1/KPNA6 although it does facilitate translocation of ORC6 to the nucleus (Ghosh et al. 2011).

Literature References
PubMed ID Title Journal Year
21555516 Assembly of the human origin recognition complex occurs through independent nuclear localization of its components

Ghosh, S, Vassilev, AP, Zhang, J, Zhao, Y, DePamphilis, ML

J Biol Chem 2011
Participants
Participates
Orthologous Events
Authored
Created
Cite Us!