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Drug-mediated inhibition of MET activation
Stable Identifier
R-HSA-9734091
DOI
10.3180/R-HSA-9734091.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
Negative regulation of MET activity (Homo sapiens)
Drug-mediated inhibition of MET activation (Homo sapiens)
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MET receptor tyrosine kinase (RTK) is a proto-oncogene that is frequently aberrantly activated in cancer through gene amplification and/or activating mutations that result in hypersensitivity to HGF stimulation or HGF-independent activation. Oncogenic MET activation can occur as a primary mechanism of malignant transformation or be selected secondarily, as a mechanism of resistance to therapeutics that target related RTKs, such as EGFR. MET targeted anti-cancer therapeutics, either recombinant monoclonal antibodies (MAbs) or small tyrosine kinase inhibitors (TKIs), have shown promise as a first-line agents for the treatment of solid tumors with primary MET activation or as second-line agents for the treatment of solid tumors with acquired MET-mediated resistance to other RTK-targeted therapies (reviewed in Comoglio et al. 2018).
Literature References
PubMed ID
Title
Journal
Year
29674709
Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy
Comoglio, PM
,
Boccaccio, C
,
Trusolino, L
Nat Rev Cancer
2018
Participants
Events
Anti-MET recombinant therapeutic antibodies bind MET
(Homo sapiens)
Anti-MET small tyrosine kinase inhibitors bind MET
(Homo sapiens)
Participates
as an event of
Negative regulation of MET activity (Homo sapiens)
Orthologous Events
Drug-mediated inhibition of MET activation (Bos taurus)
Drug-mediated inhibition of MET activation (Caenorhabditis elegans)
Drug-mediated inhibition of MET activation (Canis familiaris)
Drug-mediated inhibition of MET activation (Danio rerio)
Drug-mediated inhibition of MET activation (Gallus gallus)
Drug-mediated inhibition of MET activation (Mus musculus)
Drug-mediated inhibition of MET activation (Rattus norvegicus)
Drug-mediated inhibition of MET activation (Sus scrofa)
Drug-mediated inhibition of MET activation (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2021-06-15)
Reviewed
Kadambat Nair, S (2021-08-05)
Created
Orlic-Milacic, M (2021-06-15)
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