Defective Intrinsic Pathway for Apoptosis

Stable Identifier
R-HSA-9734009
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Defective Intrinsic Pathway for Apoptosis
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Defects in the regulation of the intrinsic pathway for apoptosis are involved in diseases associated with increased cell loss, such as neurodegenerative diseases, as well as in diseases associated with impaired elimination of harmful cells, such as cancer and autoimmunity. For review, please refer to Reed 2001, Lavrik et al. 2009, and Tuzlak et al. 2016.

So far, Reactome has annotated apoptosis defects associated with the loss of function of the CDKN2A gene product p14ARF in cancer, loss of function of TP53 in cancer, and CDK5 dysregulation in neurodegenerative diseases.
Literature References
PubMed ID Title Journal Year
27798841 Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis

Tuzlak, S, Kaufmann, T, Villunger, A

Genes Dev 2016
19756299 Understanding apoptosis by systems biology approaches

Lavrik, IN, Eils, R, Fricker, N, Pforr, C, Krammer, PH

Mol Biosyst 2009
11425640 Apoptosis-regulating proteins as targets for drug discovery

Reed, JC

Trends Mol Med 2001
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
neurodegenerative disease DOID:1289 degenerative disease, Neurodegenerative disease
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2021-06-14)
Reviewed
D'Eustachio, P  (2021-08-18)
Created
Orlic-Milacic, M  (2021-06-14)
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