Bile salts dissociate from FABP6

Stable Identifier
R-HSA-9733969
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Bile salts dissociate from FABP6
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Cytosolic ileal bile acid binding protein (IBABP, FABP6) (Fujita et al. 1995) mediates the intracellular binding and movement of bile acids (Kurz et al. 2003) to the basolateral membrane where organic solute transporters (OSTs) export bile acids and salts into the portal circulation to be returned to the liver. It is assumed that bile acids dissociate from FABP6 by an as-yet unknown mechanism before OSTs transport them across the basolateral membrane.
Literature References
PubMed ID Title Journal Year
12486725 Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures

Thüring, H, Matter, H, Stengelin, S, Kurz, M, Brachvogel, V, Kramer, W

Proteins 2003
7588781 Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein

Fujita, M, Hatakeyama, K, Sato, E, Fujii, H, Ono, T, Kanda, T

Eur J Biochem 1995
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Authored
Jassal, B  (2021-06-14)
Reviewed
D'Eustachio, P  (2021-06-21)
Created
Jassal, B  (2021-06-14)
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