Reactome | SLC51A:SLC51B transports bile salts from cytosol to extracellular region

SLC51A:SLC51B transports bile salts from cytosol to extracellular region

Stable Identifier

R-HSA-9733964

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

Synonyms

OSTA:OSTB exports bile salts from enterocytes to the portal system

ReviewStatus

5/5

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SLC51A:SLC51B transports bile salts from cytosol to extracellular region

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Bile salt and acid uptake across the apical membrane of ileal enterocytes is mediated mainly by the apical sodium-dependent bile acid transporter, ASBT, whereas basolateral efflux into the portal blood system is mediated largely by the heterodimeric organic solute transporter SLC51A:SLC51B (OSTA:OSTB) (Seward et al. 2003, Ballatori et al. 2005). Heterodimerization of SLC51 alpha and beta subunits is required not only for plasma membrane localisation but also for increased stability of the proteins (Li et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17650074	Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter Li, N, Cui, Z, Fang, F, Lee, JY, Ballatori, N	Biochem J	2007
16317684	OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia Ballatori, N, Christian, WV, Lee, JY, Dawson, PA, Soroka, CJ, Boyer, JL, Madejczyk, MS, Li, N	Hepatology	2005