SLC51A:SLC51B transports bile salts from cytosol to extracellular region

Stable Identifier
R-HSA-9733964
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
OSTA:OSTB exports bile salts from enterocytes to the portal system
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Bile salt and acid uptake across the apical membrane of ileal enterocytes is mediated mainly by the apical sodium-dependent bile acid transporter, ASBT, whereas basolateral efflux into the portal blood system is mediated largely by the heterodimeric organic solute transporter SLC51A:SLC51B (OSTA:OSTB) (Seward et al. 2003, Ballatori et al. 2005). Heterodimerization of SLC51 alpha and beta subunits is required not only for plasma membrane localisation but also for increased stability of the proteins (Li et al. 2007).

Literature References
PubMed ID Title Journal Year
16317684 OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia

Ballatori, N, Christian, WV, Lee, JY, Dawson, PA, Soroka, CJ, Boyer, JL, Madejczyk, MS, Li, N

Hepatology 2005
17650074 Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter

Li, N, Cui, Z, Fang, F, Lee, JY, Ballatori, N

Biochem J 2007
Participants
Participates
Catalyst Activity

bile acid transmembrane transporter activity of SLC51A:SLC51B [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!