SLC51A:SLC51B transports bile salts from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
OSTA:OSTB exports bile salts from enterocytes to the portal system
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Bile salt and acid uptake across the apical membrane of ileal enterocytes is mediated mainly by the apical sodium-dependent bile acid transporter, ASBT, whereas basolateral efflux into the portal blood system is mediated largely by the heterodimeric organic solute transporter SLC51A:SLC51B (OSTA:OSTB) (Seward et al. 2003, Ballatori et al. 2005). Heterodimerization of SLC51 alpha and beta subunits is required not only for plasma membrane localisation but also for increased stability of the proteins (Li et al. 2007).

Literature References
PubMed ID Title Journal Year
17650074 Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter

Fang, F, Cui, Z, Ballatori, N, Lee, JY, Li, N

Biochem J 2007
16317684 OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia

Boyer, JL, Christian, WV, Ballatori, N, Soroka, CJ, Dawson, PA, Lee, JY, Li, N, Madejczyk, MS

Hepatology 2005
Catalyst Activity

bile acid transmembrane transporter activity of SLC51A:SLC51B [plasma membrane]

Orthologous Events
Cross References
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