Reactome | Expression of NKX2-5 in cardiogenesis

Expression of NKX2-5 in cardiogenesis

Stable Identifier

R-HSA-9733772

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

3/5

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The NKX2-5 (NKX2.5) gene is transcribed to yield mRNA and the mRNA is translated to yield NKX2-5 protein (inferred from mouse homologs). In cardiac progenitors, NKX2-5 is initially activated by MESP1 (inferred from mouse homologs) and then, as expression of MESP1 is terminated, NKX2-5 becomes regulated by GATA4 (inferred from mouse homologs). NKX2-5 is also directly activated by SMAD1:SMAD4, which may result from BMP signaling (inferred from mouse homologs). In the second heart field, MEF2C binds the promoter of the NKX2-5 gene and mediates binding of NKX2-5 to its own promoter (inferred from mouse homologs). TBX20 binds the cardiac enhancer of the NKX2-5 gene and activates transcription. GATA4 and NKX2-5 regulate each other's expression during cardiogenesis.

Literature References

PubMed ID	Title	Journal	Year
25187301	Dual reporter MESP1 mCherry/w-NKX2-5 eGFP/w hESCs enable studying early human cardiac differentiation den Hartogh, SC, Mummery, CL, Elliott, DA, Davis, RP, Passier, R, Schreurs, C, Monshouwer-Kloots, JJ	Stem Cells	2015
26783251	A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors den Hartogh, SC, Mummery, CL, Wolstencroft, K, Passier, R	Sci Rep	2016