Reactome | Expression of GATA4 in cardiogenesis

Expression of GATA4 in cardiogenesis

Stable Identifier

R-HSA-9733705

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

3/5

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The GATA4 gene is transcribed to yield mRNA and the mRNA is translated to yield GATA4 protein (inferred from mouse homologs). MESP1 binds the promoter of the GATA4 gene and activates transcription (inferred from mouse homologs). GATA4 is expressed in MESP1-positive cardiac progenitors (den Hartogh et al. 2016) of both the first heart field and second heart field (inferred from mouse homologs). After activation by MESP1, GATA4 is regulated by NKX2-5 (Riazi et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19479054	NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes Riazi, AM, Takeuchi, JK, Hornberger, LK, Zaidi, SH, Amini, F, Coles, J, Bruneau, BG, Van Arsdell, GS	PLoS One	2009
26783251	A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors den Hartogh, SC, Wolstencroft, K, Mummery, CL, Passier, R	Sci Rep	2016