Viral Spike Binds to ACE2 on Uninfected Cell

Stable Identifier
R-HSA-9733495
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
plasma membrane
ReviewStatus
5/5
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Viral Spike Binds to ACE2 on Uninfected Cell
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Excess SARS-CoV-2 spike protein accumulates in the plasma membrane, apparently leaking from transport processes in the ER-Golgi network (Buchrieser et al, 2021; Cattin-Ortolá et al, 2021). It binds to glycosylated angiotensin converting enzyme 2 (ACE2) embedded within an adjacent cell plasma membrane (Zhang et al 2020; Sanders et al, 2021).
Literature References
PubMed ID Title Journal Year
33051876 Syncytia formation by SARS-CoV-2-infected cells

Bruel, T, Guivel-Benhassine, F, Mouquet, H, Planas, D, Porrot, F, Rajah, MM, Buchrieser, J, Casartelli, N, van der Werf, S, Schwartz, O, Monel, B, Hubert, M, Dufloo, J, Planchais, C

EMBO J 2020
33890572 SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

Donlic, A, Padera, RF, Suzuki, S, Jumper, CC, Ploss, A, Holehouse, AS, Tamura, T, Bracha, D, Saeed, M, Levental, I, Castello-Serrano, I, Brangwynne, CP, Tavares, AH, Kim, H, Levy, BD, Ackerman, PJ, Sanders, DW, Kenney, D, Douam, F

Elife 2021
34504087 Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

James, LC, Papa, G, Cattin-Ortolá, J, Maslen, SL, Munro, S, Welch, LG

Nat Commun 2021
32125455 Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Li, Y, Penninger, JM, Zhang, H, Slutsky, AS, Zhong, N

Intensive Care Med 2020
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2022-08-18)
Reviewed
Gillespie, ME  (2022-05-10)
Created
Stephan, R  (2021-06-04)
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