CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1

Stable Identifier
R-HSA-9733331
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1
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GRB2:SOS1 transiently associates with phosphorylated CSF1R after CSF1R undergoes an initial wave of autophosphorylation (Wang et al. 1999). GRB2:SOS1 then dissociates from CSF1R.
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Inferred From
Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1 (Mus musculus)
Authored
May, B  (2021-05-25)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2021-06-03)
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