Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL

Stable Identifier
R-HSA-9733323
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL
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CBL binds the phosphorylated CSF1R and is phosphorylated (inferred from mouse homologs). CBL is observed to bind phosphotyrosine-969 but mutation of tyrosine-561 has a greater effect on phosphoryation of CBL and multiubiquitination of CSF1R by CBL (inferred from mouse homologs). Based on response to inhibitors, the phosphorylation of CBL is catalyzed by SRC family kinases (inferred from mouse homologs).
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Catalyst Activity

protein tyrosine kinase activity of CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane]

Physical Entity
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl (Mus musculus)
Authored
May, B  (2021-05-25)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2021-06-03)
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