p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL

Stable Identifier
R-HSA-9733316
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After CBL is phosphorylated and binds CSF1R, CBL autopolyubiquitinates and polyubiquitinates CSF1R (inferred from mouse homologs). The ubiquitination of CSF1R results in a subsequent wave of phosphorylation by CSF1R and the internalization and proteolysis of CSF1R (inferred from mouse homologs). Thus multiubiquitination of CSF1R is required for full activity of CSF1R and for termination of signaling by CSF1R.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane]

Physical Entity
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Inferred From
p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12 (Mus musculus)
Authored
May, B  (2021-05-25)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2021-06-03)
Cite Us!