YBX1 binds COL1A2 gene promoter

Stable Identifier
R-HSA-9733247
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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YBX1 binds COL1A2 gene promoter
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The transcription factor YBX1 (also known as YB1), activated by ERK-mediated phosphorylation in response to interferon-gamma (IFNG) signaling, binds to SMAD3 at the promoter of the collagen I gene COL1A2. YBX1 prevents recruitment of the histone acetyltransferase EP300 (p300) to the COL1A2 promoter and represses COL1A2 transcription (Higashi, Iganaki, Suzuki et al. 2003; Higashi, Iganaki, Fujimori et al. 2003). YBX1 is thought to be the key mediator of the anti-fibrotic effect of IFNG signaling (Dooley et al. 2006).
Literature References
PubMed ID Title Journal Year
12917425 Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3

Higashi, K, Nakao, A, Nakatsuka, I, Kaneko, H, Inagaki, Y, Fujimori, K

J Biol Chem 2003
12446674 Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma

Mitsui, S, Higashi, K, Mauviel, A, Suzuki, N, Nakatsuka, I, Kaneko, H, Inagaki, Y

J Biol Chem 2003
16278212 Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects

Gressner, AM, En-Nia, A, Floege, J, Said, HM, Mertens, PR, Dooley, S

J Biol Chem 2006
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Authored
Orlic-Milacic, M  (2021-06-01)
Reviewed
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2021-06-01)
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