JAK1-activated RAF1 phosphorylates MAPKs

Stable Identifier
R-HSA-9732753
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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JAK1-activated RAF1 phosphorylates MAPKs
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RAF1, activated downstream of IFNG (interferon-gamma) in a JAK1-dependent and RAS-independent manner, phosphorylates ERKs: MAPK1 (ERK2) and MAPK3 (ERK1) (Sakatsume et al. 1998). IFNG-mediated activation of ERKs may contribute to transient attenuation of TGF-beta signaling through ERK-mediated phosphorylation of SMAD2 and SMAD3, but a long-term effect depends on IFNG-mediated transcription of SMAD7, an inhibitor of TGF-beta signaling (Ulloa et al. 1999).
Literature References
PubMed ID Title Journal Year
9446616 Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent

Stancato, LF, Finbloom, DS, David, M, Pierce, J, Sakatsume, M, Saharinen, P, Larner, AC, Silvennoinen, O

J Biol Chem 1998
Participants
Input
Output
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as an event of
Catalyst Activity

protein kinase activity of IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane]

Physical Entity
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Homo sapiens)
Activity
protein kinase activity (GO:0004672)
Orthologous Events
JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)
JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)
JAK1-activated RAF1 phosphorylates MAPKs (Gallus gallus)
JAK1-activated RAF1 phosphorylates MAPKs (Mus musculus)
JAK1-activated RAF1 phosphorylates MAPKs (Rattus norvegicus)
JAK1-activated RAF1 phosphorylates MAPKs (Sus scrofa)
Authored
Orlic-Milacic, M  (2021-09-07)
Created
Orlic-Milacic, M  (2021-05-31)
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