JAK1-mediated phosphorylation of RAF1

Stable Identifier
R-HSA-9732738
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
3/5
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JAK1-mediated phosphorylation of RAF1
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In response to IFNG (interferon-gamma) treatment, JAK1 mediates phosphorylation of RAF1 on an unknown tyrosine residue. As there is direct binding between JAK1 and RAF1, and as JAK1 tyrosine kinase activity is necessary, it is plausible that JAK1 is the tyrosine kinase that acts on RAF1, but indirect JAK1-mediated phosphorylation of RAF1 has not been excluded (Sakatsume et al. 1998).
Literature References
PubMed ID Title Journal Year
9446616 Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent

Stancato, LF, Finbloom, DS, David, M, Pierce, J, Sakatsume, M, Saharinen, P, Larner, AC, Silvennoinen, O

J Biol Chem 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane]

Physical Entity
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
JAK1-mediated phosphorylation of RAF1 (Bos taurus)
JAK1-mediated phosphorylation of RAF1 (Canis familiaris)
JAK1-mediated phosphorylation of RAF1 (Gallus gallus)
JAK1-mediated phosphorylation of RAF1 (Mus musculus)
JAK1-mediated phosphorylation of RAF1 (Rattus norvegicus)
JAK1-mediated phosphorylation of RAF1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2021-09-07)
Created
Orlic-Milacic, M  (2021-05-31)
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