IFNG signaling activates MAPKs

Stable Identifier
R-HSA-9732724
Type
Pathway
Species
Homo sapiens
ReviewStatus
3/5
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IFNG signaling activates MAPKs
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Interferon-gamma (IFNG) signaling results in transient activation of MAPK1 (ERK2) and MAPK3 (ERK1) (Sakatsume et al. 1998, Ulloa et al. 1999). IFNG-mediated MAPK (ERK) activation is JAK1-dependent and RAS-independent (Sakatsume et al. 1998). It is thought to occur through JAK1-meidated phosphorylation of RAF1 (Sakatsume et al. 1998).
Literature References
PubMed ID Title Journal Year
9446616 Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent

Stancato, LF, Finbloom, DS, David, M, Pierce, J, Sakatsume, M, Saharinen, P, Larner, AC, Silvennoinen, O

J Biol Chem 1998
10067896 Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway

Doody, J, Massagué, J, Ulloa, L

Nature 1999
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Orthologous Events
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IFNG signaling activates MAPKs (Sus scrofa)
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BioModels Database
Authored
Orlic-Milacic, M  (2021-09-07)
Created
Orlic-Milacic, M  (2021-05-31)
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