ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine

Stable Identifier
R-HSA-9731661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-dAMP and water to form dIMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011). Scaletti et al. (2021) suggest that under physiological conditions this reaction could enable the detoxification and salvage of methylated adenosine nucleotides.

Literature References
PubMed ID Title Journal Year
21755941 Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates

Murakami, E, Bao, H, Mosley, RT, Du, J, Sofia, MJ, Furman, PA

J Med Chem 2011
32144205 MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

Scaletti, ER, Vallin, KS, Bräutigam, L, Sarno, A, Warpman Berglund, U, Helleday, T, Stenmark, P, Jemth, AS

J Biol Chem 2020
Participants
Participates
Catalyst Activity

N6-mAMP deaminase activity of ADAL:Zn [cytosol]

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