Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-dAMP and water to form dIMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011). Scaletti et al. (2021) suggest that under physiological conditions this reaction could enable the detoxification and salvage of methylated adenosine nucleotides.
Warpman Berglund, U,
N6-mAMP deaminase activity of ADAL:Zn [cytosol]