ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-dAMP and water to form dIMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011). Scaletti et al. (2021) suggest that under physiological conditions this reaction could enable the detoxification and salvage of methylated adenosine nucleotides.

Literature References
PubMed ID Title Journal Year
32144205 MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

Vallin, KS, Jemth, AS, Scaletti, ER, Stenmark, P, Helleday, T, Sarno, A, Warpman Berglund, U, Bräutigam, L

J Biol Chem 2020
21755941 Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates

Furman, PA, Sofia, MJ, Du, J, Bao, H, Murakami, E, Mosley, RT

J Med Chem 2011
Catalyst Activity

N6-mAMP deaminase activity of ADAL:Zn [cytosol]

Orthologous Events
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