nsp16 localizes to the nucleus

Stable Identifier
R-HSA-9731274
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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nsp16 localizes to the nucleus
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SARS-CoV-2 nsp16 localizes in the nucleus upon SARS-CoV-2 infection, and when expressed in human cells, where it disrupts global mRNA splicing (Banerjee et al, 2020).
Literature References
PubMed ID Title Journal Year
33080218 SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

Thai, J, Bruce, EA, Honson, DD, Ollikainen, N, Botten, JW, Miller, ZD, Voorhees, RM, Goldfarb, D, Guttman, M, Schmidt, MM, Chow, A, Blanco, MR, Quinodoz, SA, Majumdar, D, Bhat, P, Lin, AE, Stewart, DG, Banerjee, AK, Loney, C, Rihn, SJ, De Lorenzo, G, Chen, LM

Cell 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-05-17)
Created
Stephan, R  (2021-05-19)
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