SARS-CoV-1 3a binds to caspase-1

Stable Identifier
R-HSA-9731057
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SARS-CoV-1 3a binds to caspase-1
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SARS-CoV-1 viroporin 3a is a membrane protein that translocates to the plasma membrane and, via shedding, to other cells. It forms a homotetrameric inward-rectifying potassium ion channel by itself, causing cell death (Chan CM et al. 2009; Freundt EC et al. 2010; Yue Y et al. 2018). Additionally, monomeric 3a directly binds to and activates caspase-1 to cleave interleukin 1 beta thus contributing to the necrotic cell death (Yue Y et al, 2018).
Literature References
PubMed ID Title Journal Year
19398035 The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function

Zhai, S, Tsoi, H, Tsui, SK, Yao, X, Chan, CM, Wong, CO, Chan, WM, Chan, WY, Chan, HY

Int. J. Biochem. Cell Biol. 2009
30185776 SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

Shi, CS, Hwang, IY, Kehrl, JH, Xiao, X, Kamenyeva, O, Nabar, NR, Yue, Y, Wang, M

Cell Death Dis 2018
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2021-05-07)
Reviewed
D'Eustachio, P  (2021-01-26)
Created
Stephan, R  (2021-05-12)
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