SARS-CoV-1 3a tetramer binds to CAV1

Stable Identifier
R-HSA-9731034
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
endoplasmic reticulum-Golgi intermediate compartment, Golgi membrane
ReviewStatus
5/5
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SARS-CoV-1 3a tetramer binds to CAV1
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SARS-CoV-1 viroporin 3a is a membrane protein that translocates to the plasma membrane and, via shedding, to other cells. It forms a homotetrameric inward-rectifying potassium ion channel. While located in the ERGIC or Golgi apparatus it binds to the regulator and scaffolding protein caveolin-1 (CAV1). Through its interaction with CAV1, the 3a protein may regulate virus uptake, as well as the trafficking of structural proteins (Padhan et al. 2007).
Literature References
PubMed ID Title Journal Year
17947532 Severe acute respiratory syndrome coronavirus Orf3a protein interacts with caveolin

Lee, MY, Hui, PY, Cheung, CY, Peiris, JSM, Hussain, A, Jameel, S, Tanwar, C, Padhan, K

J Gen Virol 2007
Participants
Input
Output
Participates
as an event of
Orthologous Events
SARS-CoV-2 3a tetramer binds to CAV1 (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2021-05-07)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-05-12)
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