Severe acute respiratory syndrome coronavirus type 1 (SARS-CoV-1) open reading frame 6 protein (6) antagonizes type I interferon (IFN) production and signaling pathways by blocking nuclear import of signal transducer and activator of transcription 1-alpha/beta (STAT1) (Kopecky‑Bromberg SA et al. 2007; Frieman M et al. 2007). SARS-CoV-1 6 was found to bind to the C-terminal domain of nuclear pore complex-interacting protein family member B3 (NPIPB3) in vitro (Huang SH et al. 2017). Confocal imaging revealed a close co-localization of the viral 6 protein with NPIPB3 in human promonocyte HL-CZ cells. The dual luciferase reporter assay, STAT1 subcellular localization, and Western blotting analysis suggest that the interaction of SARS CoV 6 and NPIPB3 reduced the antagonistic effect of SARS-CoV 6 in HL-CZ cells expressing single or both of 6 and NPIPB3 (Huang SH et al. 2017).