Reactome | Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA

Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA

Stable Identifier

R-HSA-9730767

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Alkylating chemotherapeutic drugs from the triazene group, dacarbazine (van Delft 1992), procarbazine (Wiestler et al. 1984 - study done in rats), temozolomide (Plummer et al. 2005), and streptozocin (streptozotocin) (Bennett and Pegg 1981 - study done in rats), produce N7-methylguanine adducts on double-stranded DNA (7meG-dsDNA). 7-methylguanine is the predominant methylation adduct produced by monofunctional alkylating chemotherapeutics, accounting for 60-80% of total alkylating lesions in DNA (reviewed by Fu et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
1638694	Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine van den Ende, AM, van Delft, JH, Ouwerkerk, J, Keizer, HJ, Baan, RA	Carcinogenesis	1992
6746716	DNA methylation in maternal, fetal and neonatal rat tissues following perinatal administration of procarbazine Wiestler, OD, Ivankovic, S, Kleihues, P, Rice, JM	J Cancer Res Clin Oncol	1984
15867241	Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1 Calvert, AH, Middleton, MR, McHugh, P, McGown, G, Watson, AJ, Olsen, A, Plummer, ER, Thorncroft, M, Boddy, AV, Margison, GP, Hickson, I, Jones, C, Curtin, NJ, Harris, AL, Newell, DR	Clin Cancer Res	2005