Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA

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R-HSA-9730767
Type
Reaction [omitted]
Species
Homo sapiens
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Alkylating chemotherapeutic drugs from the triazene group, dacarbazine (van Delft 1992), procarbazine (Wiestler et al. 1984 - study done in rats), temozolomide (Plummer et al. 2005), and streptozocin (streptozotocin) (Bennett and Pegg 1981 - study done in rats), produce N7-methylguanine adducts on double-stranded DNA (7meG-dsDNA). 7-methylguanine is the predominant methylation adduct produced by monofunctional alkylating chemotherapeutics, accounting for 60-80% of total alkylating lesions in DNA (reviewed by Fu et al. 2012).

Literature References
PubMed ID Title Journal Year
6746716 DNA methylation in maternal, fetal and neonatal rat tissues following perinatal administration of procarbazine

Wiestler, OD, Kleihues, P, Rice, JM, Ivankovic, S

J Cancer Res Clin Oncol 1984
1638694 Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine

van Delft, JH, van den Ende, AM, Keizer, HJ, Ouwerkerk, J, Baan, RA

Carcinogenesis 1992
15867241 Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1

Plummer, ER, Middleton, MR, Jones, C, Olsen, A, Hickson, I, McHugh, P, Margison, GP, McGown, G, Thorncroft, M, Watson, AJ, Boddy, AV, Calvert, AH, Harris, AL, Newell, DR, Curtin, NJ

Clin Cancer Res 2005
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