Alkylating chemotherapeutic drugs from the triazene group, dacarbazine (van Delft 1992), procarbazine (Wiestler et al. 1984 - study done in rats), temozolomide (Plummer et al. 2005), and streptozocin (streptozotocin) (Bennett and Pegg 1981 - study done in rats), produce N7-methylguanine adducts on double-stranded DNA (7meG-dsDNA). 7-methylguanine is the predominant methylation adduct produced by monofunctional alkylating chemotherapeutics, accounting for 60-80% of total alkylating lesions in DNA (reviewed by Fu et al. 2012).
Wiestler, OD, Kleihues, P, Rice, JM, Ivankovic, S
van Delft, JH, van den Ende, AM, Keizer, HJ, Ouwerkerk, J, Baan, RA
Plummer, ER, Middleton, MR, Jones, C, Olsen, A, Hickson, I, McHugh, P, Margison, GP, McGown, G, Thorncroft, M, Watson, AJ, Boddy, AV, Calvert, AH, Harris, AL, Newell, DR, Curtin, NJ
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