Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA

Stable Identifier
R-HSA-9730736
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA
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Alkylating chemotherapeutic drugs from the triazene group, dacarbazine (Braybrook et al. 2000), temozolomide (Deans and Tisdale 1992), and streptozocin (streptozotocin) (Bennett and Pegg 1981 - study was performed in rats), and probably procarbazine, produce 3-metyladenine adducts on DNA (3meA-dsDNA) (reviewed by Fu et al. 2012).
Literature References
PubMed ID Title Journal Year
1562991 Antitumour imidazotetrazines XXVIII 3-methyladenine DNA glycosylase activity in cell lines sensitive and resistant to temozolomide

Deans, B, Tisdale, MJ

Cancer Lett 1992
10663625 Evaluation of the alkaline comet assay and urinary 3-methyladenine excretion for monitoring DNA damage in melanoma patients treated with dacarbazine and tamoxifen

Braybrooke, JP, Houlbrook, S, Crawley, JE, Propper, DJ, O'Byrne, KJ, Stratford, IJ, Harris, AL, Shuker, DE, Talbot, DC

Cancer Chemother Pharmacol 2000
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Inferred From
Streptozocin (streptozotocin) produces 3-methyladenine in dsDNA (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2021-05-11)
Reviewed
Kadambat Nair, S  (2021-07-28)
Created
Orlic-Milacic, M  (2021-05-10)
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