SARS-CoV-2 3CLpro dimer binds to STING

Stable Identifier
R-HSA-9730501
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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SARS-CoV-2 3CLpro dimer binds to STING
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STING is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon. RNA viral infection can also lead to the activation of STING through viral–cellular membrane fusion and viral infection-induced mitochondrial damage. SARS-CoV-2 nsp5 protease (3CLpro) has the ability to specifically antagonize the immune activation induced by cGAS-STING in human lung cell line A549 and human Huh-7 cell line, by binding to STING and inhibiting its K63-ubiquitin-mediated modification, leading to mediation of NF-kappaB signaling. Moreover, the recruitment of TBK1 and IKKbeta by STING was inhibited by 3CLpro (Rui et al, 2021).
Literature References
PubMed ID Title Journal Year
33723219 Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins

Rui, Y, Su, J, Shen, S, Hu, Y, Huang, D, Zheng, W, Lou, M, Shi, Y, Wang, M, Chen, S, Zhao, N, Dong, Q, Cai, Y, Xu, R, Zheng, S, Yu, XF

Signal Transduct Target Ther 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2021-05-03)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-05-07)
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