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p-S172-IKBKE:p-S172-IKBKE [cytosol]
Stable Identifier
R-HSA-9730458
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S172-IKBKE homodimer, activated IKBKE homodimer
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Recruitment of IRF3,IRF7 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Phosphorylation and release of IRF7 (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Phosphorylation of TBK1/IKBKE (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Recruitment of IRF7 to TRAF6 (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
IKKε (IKBKE) is phosphorylated within the activated TLR3 complex (Homo sapiens)
p-S172-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
p-S172-IKBKE:p-S172-IKBKE [cytosol] (Homo sapiens)
Participants
components
x 2
p-S172-IKBKE [cytosol]
(Homo sapiens)
Participates
as a component of
p-S172-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
as an output of
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Homo sapiens)
as a member of
p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
This entity regulates
Positively
Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE
(Homo sapiens)
Inferred To
p-S172-IKBKE:p-S172-IKBKE [cytosol]
(Bos taurus)
p-S172-IKBKE:p-S172-IKBKE [cytosol]
(Canis familiaris)
p-S172-IKBKE:p-S172-IKBKE [cytosol]
(Danio rerio)
p-S172-IKBKE:p-S172-IKBKE [cytosol]
(Drosophila melanogaster)
p-S172-IKBKE:p-S172-IKBKE [cytosol]
(Gallus gallus)
p-S172-IKBKE:p-S172-IKBKE [cytosol]
(Mus musculus)
p-S172-IKBKE:p-S172-IKBKE [cytosol]
(Rattus norvegicus)
p-S172-IKBKE:p-S172-IKBKE [cytosol]
(Sus scrofa)
p-S172-IKBKE:p-S172-IKBKE [cytosol]
(Xenopus tropicalis)
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