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IKBKE:IKBKE [cytosol]
Stable Identifier
R-HSA-9730425
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
IKBKE homodimer
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
TBK1 or IKBKE forms homodimers (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Phosphorylation of TBK1/IKBKE (Homo sapiens)
TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
TBK1, IKBKE form homodimers (Homo sapiens)
dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Homo sapiens)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
IKBKE:IKBKE [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
23453969
IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex
Shen, RR
,
Hahn, WC
,
Chen, ZJ
,
Xu, M
,
Lock, YJ
,
Zhou, AY
,
Kim, E
Cell Rep
2013
Participants
components
x 2
IKBKE [cytosol]
(Homo sapiens)
Participates
as an input of
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Homo sapiens)
as a component of
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
as a member of
TBK1:TBK1, IKBKE:IKBKE [cytosol] (Homo sapiens)
Inferred To
IKBKE:IKBKE [cytosol]
(Bos taurus)
IKBKE:IKBKE [cytosol]
(Canis familiaris)
IKBKE:IKBKE [cytosol]
(Danio rerio)
IKBKE:IKBKE [cytosol]
(Drosophila melanogaster)
IKBKE:IKBKE [cytosol]
(Gallus gallus)
IKBKE:IKBKE [cytosol]
(Mus musculus)
IKBKE:IKBKE [cytosol]
(Rattus norvegicus)
IKBKE:IKBKE [cytosol]
(Sus scrofa)
IKBKE:IKBKE [cytosol]
(Xenopus tropicalis)
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