KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol

Stable Identifier
R-HSA-9729870
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol
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The KCNJ2 inward rectifying potassium channel preferentially transports K+ ions from the extracellular region to the cytosol (inferred from the mouse homolog). In type III taste cells, the increase in cytosolic H+ caused by acidic compounds inhibits the activity of KCNJ2 (inferred from mouse homologs in Ye et al. 2016).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inward rectifier potassium channel activity of KCNJ2 [plasma membrane]

Physical Entity
KCNJ2 [plasma membrane] (Homo sapiens)
Activity
inward rectifier potassium channel activity (GO:0005242)
This event is regulated
Negatively by
Regulator
H+ [cytosol]
Inferred From
Kcnj2 transports K+ from the extracellular region to the cytosol (Mus musculus)
Cross References
Rhea
Authored
May, B  (2021-04-30)
Reviewed
Jiang, P  (2021-08-08)
Created
May, B  (2021-05-03)
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