SARS-CoV-2 3CLpro dimer cleaves TAB1

Stable Identifier
R-HSA-9729704
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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SARS-CoV-2 3CLpro dimer cleaves TAB1
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SARS-CoV-2 nsp5 protease (3CLpro) specifically cleaves TAB1 at two sites and decreases its level in SARS-CoV-2 infected cells. Mutants with inhibited 3CLpro activity show no decrease in TAB1 levels (Moustaqil et al, 2021). Intact TAB1 is part of a complex that regulates the activity of TAK1, a regulator of the NFκB pathway and the signaling through the MAP kinases pathway in response to different stimuli and upon viral and bacterial infections (Dai et al, 2012; Malireddi et al, 2019).
Literature References
PubMed ID Title Journal Year
31850239 ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

Kesavardhana, S, Malireddi, RKS, Kanneganti, TD

Front Cell Infect Microbiol 2019
22941947 TAK1, more than just innate immunity

Aye Thu, C, Cheung, PC, Xi, J, Liu, XY, Dai, L

IUBMB Life 2012
33372854 SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Moustaqil, M, Jacques, D, Gambin, Y, Rudolffi-Soto, P, Freiberg, AN, Hunter, DJB, Chiu, HP, Bhumkar, A, Lee, B, Van Tol, S, Ollivier, E, Sierecki, E, Stevens, C

Emerg Microbes Infect 2021
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Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of 3CLp dimer [cytosol]

Physical Entity
3CLp dimer [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-05-03)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-05-03)
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