SARS-CoV-2 N protein binds STAT1, STAT2

Stable Identifier
R-HSA-9729454
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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SARS-CoV-2 N protein binds STAT1, STAT2
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Type I interferon (IFN-I) immune signaling is dampened in COVID-19, and the SARS-CoV-2 nucleocapsid (N) protein produces this effect (Li et al, 2020; Oh & Shin, 2021). Specifically, N binds to both STAT1 and STAT2, prevents their phosphorylation, and suppresses their nuclear translocation induced by IFN. The N-terminal 1-361 amino acids of SARS-CoV-2 N protein are sufficient for its IFN-I antagonizing activity (Mu et al, 2020).
Literature References
PubMed ID Title Journal Year
33801464 SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response

Oh, SJ, Shin, OS

Cells 2021
32953130 SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

Mu, J, Fang, Y, Yang, Q, Shu, T, Wang, A, Huang, M, Jin, L, Deng, F, Qiu, Y, Zhou, X

Cell Discov 2020
32589897 The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

Li, JY, Liao, CH, Wang, Q, Tan, YJ, Luo, R, Qiu, Y, Ge, XY

Virus Res 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Shamovsky, V  (2021-10-27)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-04-28)
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