Nucleoprotein is SUMOylated

Stable Identifier
R-HSA-9729307
Type
Reaction
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
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Nucleoprotein is SUMOylated
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

N protein is sumoylated at a lysine residue. Abolition of sumoylation of nucleoprotein significantly decreases homo-oligomerisation of the protein (Li et al, 2005)

Literature References
PubMed ID Title Journal Year
15848177 Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus

Liu, DX, Xiao, H, Li, FQ, Tam, JP

FEBS Lett. 2005
Participants
Input
Output
Participates
as an event of
Inferred From
Nucleoprotein is SUMOylated (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2021-05-08)
Acencio, ML  (2020-09-09)
Created
Stephan, R  (2021-04-27)
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