Nucleoprotein is methylated by PRMT1

Stable Identifier
R-HSA-9729283
Type
Reaction
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Protein arginine methyltransferase 1 (PRMT1) methylates SARS-CoV-2 nucleoprotein on two arginines (R95 and R177). This modification is required for its RNA binding capacity, since treatment with a type I PRMT inhibitor (MS023) or substitution of R95K or R177K inhibited interaction with the 5’-UTR of the SARS-CoV-2 genomic RNA. Pre-treatment of VeroE6 cells with MS023 significantly reduced SARS-CoV-2 replication (Cai et al, 2021).

Literature References
PubMed ID Title Journal Year
34029587 Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication

Richard, S, Liang, C, Wang, Z, Yu, Z, Cai, T

J Biol Chem 2021
Participants
Participates
Catalyst Activity

protein-arginine omega-N asymmetric methyltransferase activity of PRMT1 [cytosol]

This event is regulated
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
Cite Us!