Nucleoprotein is ADP-ribosylated

Stable Identifier
R-HSA-9729279
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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Nucleoprotein is ADP-ribosylated
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Nucleoprotein (N) is ADP-ribosylated. The modification is maintained both in the cell and in virions (Grunewald et al, 2018). Members of the protein mono-ADP-ribosyltransferase (PARP) enzyme family are thought to catalyze this reaction (Fehr et al. 2020)

Literature References
PubMed ID Title Journal Year
32029454 The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions

Aikawa, M, Fehr, AR, Higashi, H, Kerr, CM, Mukai, S, Singh, SA

Genes Dev. 2020
29199039 The coronavirus nucleocapsid protein is ADP-ribosylated

Perlman, S, Grunewald, ME, Fehr, AR, Athmer, J

Virology 2018
Participants
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Output
Participates
as an event of
Catalyst Activity

NAD+ ADP-ribosyltransferase activity of PARPs [cytosol]

Physical Entity
PARPs [cytosol] (Homo sapiens)
Activity
NAD+ ADP-ribosyltransferase activity (GO:0003950)
Inferred From
Nucleoprotein is ADP-ribosylated (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2021-05-09)
Acencio, ML  (2020-09-09)
Created
Stephan, R  (2021-04-28)
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