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SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to EEF1A1
Stable Identifier
R-HSA-9727944
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 modulates host translation machinery (Homo sapiens)
SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to EEF1A1 (Homo sapiens)
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Elongation factor 1‑alpha 1 (EEF1A1), an abundant cellular protein, binds F-actin to modulate cytokinesis and functions in delivery of aminoacyl tRNAs to the ribosome in protein synthesis. In SARS‑CoV‑1‑infected cells, nucleocapsid protein (N), the most abundant viral protein, interacts with EEF1A1, causing its aggregation and disrupting these processes (Zhou et al, 2008).
Literature References
PubMed ID
Title
Journal
Year
18448518
The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha
Cao, C
,
Wang, Q
,
Zhou, B
,
Li, X
,
Ma, Q
,
Liu, J
,
Li, P
,
Liu, X
J Virol
2008
Participants
Input
EEF1A1 [cytosol]
(Homo sapiens)
SUMO1-K62-p-S177-N dimer [cytosol]
(Human SARS coronavirus)
Output
EEF1A1:SUMO1-K62-p-S177-Ncap dimer [cytosol]
(Homo sapiens)
Participates
as an event of
SARS-CoV-1 modulates host translation machinery (Homo sapiens)
Disease
Name
Identifier
Synonyms
severe acute respiratory syndrome
DOID:2945
SARS-CoV infection, SARS
Authored
Stephan, R (2021-04-16)
Reviewed
D'Eustachio, P (2021-01-26)
Created
Stephan, R (2021-04-19)
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