SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to UBE2I

Stable Identifier
R-HSA-9727860
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to UBE2I
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As well as getting SUMOylated by SUMO-conjugating enzyme UBC9 (UBE2I), SARS-CoV-1 nucleocapsid protein (N) binds the catalytic domain of UBE2I. Through the abundance of N in infected cells, this binding may directly regulate the activity of UBE2I, affecting downstream signaling factors involved in the cell cycle, in addition to its function in the process of sumoylation (Fan et al, 2006).
Literature References
PubMed ID Title Journal Year
16998888 SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system

Qiang, B, Peng, X, Tan, X, Gao, GF, Yan, J, Fan, Z, Yuan, J, Zhou, Z, Zhuo, Y

J Med Virol 2006
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Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2021-04-16)
Reviewed
D'Eustachio, P  (2021-01-26)
Created
Stephan, R  (2021-04-19)
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