SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL

Stable Identifier
R-HSA-9727857
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SARS coronavirus nucleoprotein binds and inhibits the liver isoform of pyruvate kinase (PKL), an enzyme of the glycolysis pathway. It is reasonable to assume that this inhibition is likely to cause the death of the hepatocytes, which results in the elevation of serum alanine aminotransferase and liver dysfunction noted in most SARS patients (Wei et al, 2012).
Literature References
PubMed ID Title Journal Year
22222284 SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity

Wei, WY, Li, HC, Wang, CW, Juang, YL, Chen, CY, Ma, HC, Lo, SY, Lee, SK, Yang, CH

Arch Virol 2012
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2021-04-16)
Reviewed
D'Eustachio, P  (2021-01-26)
Created
Stephan, R  (2021-04-19)
Cite Us!