Reactome | keratinocyte of granulosum layer of epidermis

keratinocyte of granulosum layer of epidermis

Stable Identifier

R-HSA-9727357

Type

Cell

Species

Homo sapiens

Synonyms

keratinocyte of skin epidermis stratum granulosum

Locations in the PathwayBrowser

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Cytology

Organ

skin of body (UBERON:0002097)

Tissue

skin epidermis (UBERON:0001003)

Tissue Layer

stratum granulosum of epidermis (UBERON:0002069)

Cell Type

keratinocyte (CL:0000312)

Markers

Protein

FABP5 [cytosol] (Homo sapiens)

- A histological and immunohistochemical study on chronic irritant contact dermatitis.Am J Contact Dermat9,23-8(1998)van Haelst, U., van der Valk, PG., van de Kerkhof, PC., Le, TK., Schalkwijk, J.

GJB3 [plasma membrane] (Homo sapiens)

- Differential expression of the gap junction proteins connexin45, -43, -40, -31, and -26 in mouse skin.Eur J Cell Biol65,152-63(1994)Elfgang, C., Traub, O., Butterweck, A., Willecke, K.
- Multiple epidermal connexins are expressed in different keratinocyte subpopulations including connexin 31.J Invest Dermatol117,958-64(2001)Leigh, IM., Rugg, EL., Di, WL., Kelsell, DP.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.

FLG(1-4061) [cytosol] (Homo sapiens)

- Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes.J. Biol. Chem.288,17179-89(2013)Yamamoto, M., Tokura, Y., Hirakawa, S., Kabashima, K., Ohta, I., Sakabe, J., Tatsuno, K., Ito, T., Hibino, T., Motoyama, A.
- Expression of loricrin in skin disorders.Acta Derm Venereol72,407-9(1992)Juhlin, L., Magnoldo, T., Darmon, M.
- "Activated" keratinocyte phenotype is unifying feature in conditions which predispose to squamous cell carcinoma of the skin.Mod Pathol3,171-5(1990)Hsu, A., Krueger, J., McNutt, NS., Smoller, BR.
- Biosynthetic pathways of filaggrin and loricrin--two major proteins expressed by terminally differentiated epidermal keratinocytes.J Struct Biol104,150-62(1990)Steinert, PM., Steven, AC., Roop, DR., Bisher, ME.
- Interaction of the profilaggrin N-terminal domain with loricrin in human cultured keratinocytes and epidermis.J Invest Dermatol132,1206-14(2012)Demitsu, T., Presland, RB., Huard, J., Lawrence, OT., Kubota, Y., Nakagawa, T., Yoneda, K.
- Molecular basis of the skin barrier structures revealed by electron microscopy.Exp Dermatol27,841-846(2018)Kishibe, M., Igawa, S., Ishida-Yamamoto, A.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.
- Normal human epidermal keratinocytes express in vitro specific molecular forms of (pro)filaggrin recognized by rheumatoid arthritis-associated antifilaggrin autoantibodies.Mol Med3,145-56(1997)Sebbag, M., Montézin, M., Girbal-Neuhauser, E., Serre, G., Durieux, JJ., Simon, M., Croute, F.
- Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond.Br J Dermatol175,4-7(2016)McLean, WH.
- Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function.J Invest Dermatol135,454-461(2015)Wong, WJ., Seykora, JT., Simon, MC., Richardson, T., Cotsarelis, G.

PRSS3 [tertiary granule lumen] (Homo sapiens)

- Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation.J Invest Dermatol130,944-52(2010)Koyama, J., Yamamoto, M., Nakanishi, J., Hibino, T., Sato, J.
- Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation.J Invest Dermatol134,1665-1674(2014)Miyai, M., Tsuboi, R., Yamanishi, H., Matsumoto, Y., Hibino, T., Yamamoto-Tanaka, M.

HOPX [nucleoplasm] (Homo sapiens)

- Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes.Eur J Cell Biol90,279-90(2011)Kypriotou, M., Hohl, D., Ryser, S., Favre, B., Obarzanek-Fojt, M., Huber, M.

KRT1 [cytosol] (Homo sapiens)

- Epidermal differentiation: the bare essentials.J Cell Biol111,2807-14(1990)Fuchs, E.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.
- Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis.Eur J Dermatol27,247-253(2017)Totsuka, A., Kawashima, M., Omori-Miyake, M., Yagi, J., Tsunemi, Y.

CALML5 [cytosol] (Homo sapiens)

- Calmodulin-like skin protein: a new marker of keratinocyte differentiation.J Invest Dermatol116,905-9(2001)Bernard, D., Méhul, B., Schmidt, R.
- Calmodulin-like skin protein level increases in the differentiated epidermal layers in atopic dermatitis.Exp Dermatol22,836-7(2013)Donovan, M., Gollnick, H., Thomas-Collignon, A., Jammayrac, O., Ambach, A., Bernard, D., Prado, C., de Lacharriere, O.
- CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.Genes Dev29,2225-30(2015)Hollmig, ST., Lopez-Pajares, V., Boxer, LD., Sun, BK., Qu, K., Siprashvili, Z., Khavari, PA., Ransohoff, JD.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.
- Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis.Exp Dermatol15,469-77(2006)Brouard, M., Delattre, C., Bernard, D., Méhul, B., Schmidt, R.

KLK7 [cytosol] (Homo sapiens)

- LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum.J Invest Dermatol124,360-6(2005)Hovnanian, A., Wakamatsu, K., Bonnart, C., McGrath, JA., Dopping-Hepenstal, PJ., Deraison, C., Iizuka, H., O'Brien, TJ., Ishida-Yamamoto, A., Richard, G., Takahashi, H., Bitoun, E., Hashimoto, Y., Ohtsubo, S., Robinson, R.
- Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation.J Invest Dermatol134,1665-1674(2014)Miyai, M., Tsuboi, R., Yamanishi, H., Matsumoto, Y., Hibino, T., Yamamoto-Tanaka, M.

DMKN [secretory granule lumen] (Homo sapiens)

- Mice deficient for the epidermal dermokine β and γ isoforms display transient cornification defects.J Cell Sci127,2862-72(2014)Serre, G., Huchenq, A., Kezic, S., Leclerc, EA., Jonca, N.
- Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.Genomics84,384-97(2004)Katahira, S., Imai, T., Miyachi, Y., Tsukita, S., Komiya, T., Kinoshita, Y., Hayashi-Kisumi, F., Tanigawa, Y., Morita, K., Matsui, T., Ono, Y.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.
- Dermokine-β impairs ERK signaling through direct binding to GRP78.FEBS Lett586,2300-5(2012)Mitsui, S., Higashi, K., Yokoyama, C., Tachibana, T., Saito, K., Hasegawa, M.

KRTDAP [secretory granule lumen] (Homo sapiens)

- Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.Genomics84,384-97(2004)Katahira, S., Imai, T., Miyachi, Y., Tsukita, S., Komiya, T., Kinoshita, Y., Hayashi-Kisumi, F., Tanigawa, Y., Morita, K., Matsui, T., Ono, Y.
- Characterization of Kdap, a protein secreted by keratinocytes.J Invest Dermatol122,1225-34(2004)Shimizu, H., Bonkobara, M., Tezuka, T., Ariizumi, K., Cruz, PD., Akiyama, M., Tsuchida, S., Aragane, Y., McMillan, JR., Yudate, T.

KRT10 [cytosol] (Homo sapiens)

- Interaction of the profilaggrin N-terminal domain with loricrin in human cultured keratinocytes and epidermis.J Invest Dermatol132,1206-14(2012)Demitsu, T., Presland, RB., Huard, J., Lawrence, OT., Kubota, Y., Nakagawa, T., Yoneda, K.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.
- Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis.Eur J Dermatol27,247-253(2017)Totsuka, A., Kawashima, M., Omori-Miyake, M., Yagi, J., Tsunemi, Y.

LORICRIN [cytosol] (Homo sapiens)

- Immunoelectron microscopic analysis of cornified cell envelope formation in normal and psoriatic epidermis.J Histochem Cytochem44,167-75(1996)Hohl, D., Roop, DR., Iizuka, H., Watt, FM., Ishida-Yamamoto, A., Eady, RA.
- Loricrin and human skin diseases: molecular basis of loricrin keratodermas.Histol Histopathol13,819-26(1998)Takahashi, H., Iizuka, H., Ishida-Yamamoto, A.
- Expression of loricrin is negatively controlled by retinoic acid in human epidermis reconstructed in vitro.Differentiation49,39-46(1992)Bernerd, F., Magnaldo, T., Asselineau, D., Darmon, M.
- Expression of loricrin in skin disorders.Acta Derm Venereol72,407-9(1992)Juhlin, L., Magnoldo, T., Darmon, M.
- Biosynthetic pathways of filaggrin and loricrin--two major proteins expressed by terminally differentiated epidermal keratinocytes.J Struct Biol104,150-62(1990)Steinert, PM., Steven, AC., Roop, DR., Bisher, ME.
- Interaction of the profilaggrin N-terminal domain with loricrin in human cultured keratinocytes and epidermis.J Invest Dermatol132,1206-14(2012)Demitsu, T., Presland, RB., Huard, J., Lawrence, OT., Kubota, Y., Nakagawa, T., Yoneda, K.
- Molecular basis of the skin barrier structures revealed by electron microscopy.Exp Dermatol27,841-846(2018)Kishibe, M., Igawa, S., Ishida-Yamamoto, A.

SPINK5 [cytosol] (Homo sapiens)

- LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum.J Invest Dermatol124,360-6(2005)Hovnanian, A., Wakamatsu, K., Bonnart, C., McGrath, JA., Dopping-Hepenstal, PJ., Deraison, C., Iizuka, H., O'Brien, TJ., Ishida-Yamamoto, A., Richard, G., Takahashi, H., Bitoun, E., Hashimoto, Y., Ohtsubo, S., Robinson, R.
- Molecular basis of the skin barrier structures revealed by electron microscopy.Exp Dermatol27,841-846(2018)Kishibe, M., Igawa, S., Ishida-Yamamoto, A.
- LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome.Hum Mol Genet12,2417-30(2003)Hovnanian, A., Al Saati, T., Hohl, D., Harper, J., Bonnart, C., Boralevi, F., Lamant, L., Cobbold, C., D'Alessio, M., Mariotti, F., Tartaglia-Polcini, A., Micheloni, A., Bitoun, E., Mazereeuw-Hautier, J., Bodemer, C.
- Characterization and expression analysis of the Spink5 gene, the mouse ortholog of the defective gene in Netherton syndrome.Genomics85,483-92(2005)Hovnanian, A., D'Alessio, M., Levy, E., Micheloni, A., Roccasecca, RM., Descargues, P., Zambruno, G., Galliano, MF.

KPRP [cytosol] (Homo sapiens)

- Markers for Ca⁺⁺ -induced terminal differentiation of keratinocytes in vitro under defined conditions.Exp Dermatol29,1238-1242(2020)Celli, A., Jeriha, J., Gordon, M., Khurana, P., Mauro, TM., Ilic, D., Kolundzic, N.
- Keratinocyte Proline-Rich Protein Deficiency in Atopic Dermatitis Leads to Barrier Disruption.J Invest Dermatol139,1867-1875.e7(2019)Sato, Y., Oka, T., Fukayama, M., Sato, S., Nishida, H., Ishii, T., Ishikawa, S., Suga, H., Sugaya, M.
- Molecular cloning and expression of human keratinocyte proline-rich protein (hKPRP), an epidermal marker isolated from calcium-induced differentiating keratinocytes.J Invest Dermatol125,995-1000(2005)Yang, JM., You, KH., Kim, JM., Jang, S., Park, JK., Seo, EY., Lee, SC., Lee, JS., Lee, JH., Lee, WH., Lee, Y., Kim, CD., Kee, SH., Nam, KI., Seo, YJ.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.

SPRR2A [cornified envelope] (Homo sapiens)

- CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.Nucleic Acids Resnull,null(2022)Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
- The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins.J Invest Dermatol104,902-9(1995)Backendorf, C., Hohl, D., Gibbs, S., de Viragh, PA., Huber, M., Amiguet-Barras, F.
- AP-1 and ets transcription factors regulate the expression of the human SPRR1A keratinocyte terminal differentiation marker.J Biol Chem273,24683-92(1998)van de Putte, P., de Meijer, E., Backendorf, C., Fischer, DF., Sark, MW.
- Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation.J Biol Chem278,17792-9(2003)Cabral, A., Backendorf, C., Fischer, DF., Vermeij, WP.

AQP3 [plasma membrane] (Homo sapiens)

- Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3.J Biol Chem277,17147-53(2002)Ma, T., Verkman, AS., Verbavatz, JM., Hara, M., Sougrat, R.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.
- Functional expression of AQP3 in human skin epidermis and reconstructed epidermis.J Invest Dermatol118,678-85(2002)Gondran, C., Dumas, M., Gobin, R., Morand, M., Verbavatz, JM., Bonté, F., Barré, P., Sougrat, R.
- Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes.Biochim Biophys Acta1522,82-8(2001)Ota, Y., Sugiyama, Y., Inoue, S., Hara, M.

SBSN [secretory granule lumen] (Homo sapiens)

- Decreased expression of suprabasin induces aberrant differentiation and apoptosis of epidermal keratinocytes: Possible role for atopic dermatitis.J Dermatol Sci95,107-112(2019)Tokura, Y., Umayahara, T., Ikeya, S., Phadungsaksawasdi, P., Iwasaki, M., Sakabe, JI., Aoshima, M., Shimauchi, T., Nakazawa, S., Yatagai, T.
- Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.Genomics84,384-97(2004)Katahira, S., Imai, T., Miyachi, Y., Tsukita, S., Komiya, T., Kinoshita, Y., Hayashi-Kisumi, F., Tanigawa, Y., Morita, K., Matsui, T., Ono, Y.
- Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.Dev Dyn236,961-70(2007)Bazzi, H., Richardson, GD., Jahoda, CA., Fantauzzo, KA., Christiano, AM.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.

IVL [cytosol] (Homo sapiens)

- The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation.Oncogene21,738-47(2002)Bone, F., Banks, EB., Eckert, RL., Crish, JF.
- Abnormal maturation pathway of keratinocytes in psoriatic skin.Br J Dermatol112,647-53(1985)Bernard, BA., Mansbridge, JN., Vandaele, S., Darmon, M., Robinson, SM.
- Immunoelectron microscopic analysis of cornified cell envelope formation in normal and psoriatic epidermis.J Histochem Cytochem44,167-75(1996)Hohl, D., Roop, DR., Iizuka, H., Watt, FM., Ishida-Yamamoto, A., Eady, RA.
- "Activated" keratinocyte phenotype is unifying feature in conditions which predispose to squamous cell carcinoma of the skin.Mod Pathol3,171-5(1990)Hsu, A., Krueger, J., McNutt, NS., Smoller, BR.
- MON-150, a versatile monoclonal antibody against involucrin: characterization and applications.Arch Dermatol Res284,167-72(1992)Kranenborg, MH., van Erp, PE., van Duijnhoven, JL., Timmer, ED., Van de Ven, WJ., van Vlijmen-Willems, IM., de Jongh, GJ., Schalkwijk, J., Groeneveld, A.
- PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.Database (Oxford)2019,null(2019)Franzén, O., Gan, LM., Björkegren, JLM.
- Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK-3β.Cell Biochem Biophys66,523-8(2013)Landeck, L., Zheng, M., Cai, SQ., Man, XY., Li, W., Zhou, J., Chen, JQ.

KLK5 [cytosol] (Homo sapiens)

- Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes.J. Biol. Chem.288,17179-89(2013)Yamamoto, M., Tokura, Y., Hirakawa, S., Kabashima, K., Ohta, I., Sakabe, J., Tatsuno, K., Ito, T., Hibino, T., Motoyama, A.
- LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum.J Invest Dermatol124,360-6(2005)Hovnanian, A., Wakamatsu, K., Bonnart, C., McGrath, JA., Dopping-Hepenstal, PJ., Deraison, C., Iizuka, H., O'Brien, TJ., Ishida-Yamamoto, A., Richard, G., Takahashi, H., Bitoun, E., Hashimoto, Y., Ohtsubo, S., Robinson, R.
- Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation.J Invest Dermatol134,1665-1674(2014)Miyai, M., Tsuboi, R., Yamanishi, H., Matsumoto, Y., Hibino, T., Yamamoto-Tanaka, M.

Participates

as an input of

Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis (Homo sapiens)

as an output of

Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis (Homo sapiens)

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