Reactome | XDH dehydrogenates xanthine to form urate

XDH dehydrogenates xanthine to form urate

Stable Identifier

R-HSA-9727349

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Xanthine + H2O + NAD+ => urate + NADH + H+

ReviewStatus

5/5

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XDH dehydrogenates xanthine to form urate

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Cytosolic xanthine dehydrogenase (XDH) in its dehydrogenase form catalyzes the reaction of xanthine with H2O and NAD+ to form urate and NADH + H+. The active form of the enzyme is a dimer (Saksela and Raivio 1996; Yamaguchi et al. 2007). The enzyme can be converted to an oxidase form that catalyzes the reaction of xanthine with O2 to form urate and H2O2 (Ichida et al. 2012), annotated separately.

Literature References

PubMed ID	Title	Journal	Year
23203137	Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans Ichida, K, Amaya, Y, Okamoto, K, Nishino, T	Int J Mol Sci	2012
8670112	Cloning and expression in vitro of human xanthine dehydrogenase/oxidase Saksela, M, Raivio, KO	Biochem J	1996
17301077	Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate Yamaguchi, Y, Matsumura, T, Ichida, K, Okamoto, K, Nishino, T	J Biochem	2007