XDH dehydrogenates xanthine to form urate

Stable Identifier
R-HSA-9727349
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Xanthine + H2O + NAD+ => urate + NADH + H+
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Cytosolic xanthine dehydrogenase (XDH) in its dehydrogenase form catalyzes the reaction of xanthine with H2O and NAD+ to form urate and NADH + H+. The active form of the enzyme is a dimer (Saksela and Raivio 1996; Yamaguchi et al. 2007). The enzyme can be converted to an oxidase form that catalyzes the reaction of xanthine with O2 to form urate and H2O2 (Ichida et al. 2012), annotated separately.

Participants
Participates
Catalyst Activity

xanthine dehydrogenase activity of XDH dimer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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