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SLC12A3 binds SLC12A3 inhibitors
Stable Identifier
R-HSA-9725706
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Cation-coupled Chloride cotransporters (Homo sapiens)
SLC12A3 binds SLC12A3 inhibitors (Homo sapiens)
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The SLC12A3 gene encodes the thiazide-sensitive sodium-chloride cotransporter. In the distal convoluted tubules of the kidney, SLC12A3 is the major mediator of sodium and chloride reabsorption in the apical membrane of the mammalian distal convoluted tubule and contributes to general electrolyte homeostasis in the body.
Distal convoluted tubule diuretics are primarily used to treat hypertension (Wright et al. 2018). They inhibit SLC12A3 causing the body to release NaCl and water into the lumen, thereby increasing the amount of urine produced each day. This reduces water load in the body, contributing to the lowering of blood pressure and swelling (Winer et al. 1961, review Duarte & Cooper-DeHoff 2011). Thiazide diuretics (eg. chlorothiazide, cyclothiazide, diazoxide) and thiazide-like diuretics (eg. chlorthalidone, metolazone) bind to and inhibit SLC12A3. The proposed target for the candidate drugs listed here is also thought to be SLC12A3. Hydrochlorothiazide is the prototypical thiazide diuretic drug.
Literature References
PubMed ID
Title
Journal
Year
13785791
The antihypertensive actions of benzothiadiazines
WINER, BM
Circulation
1961
Participants
Input
SLC12A3 [plasma membrane]
(Homo sapiens)
SLC12A3 inhibitors [extracellular region]
Output
SLC12A3:SLC12A3 inhibitors [plasma membrane]
(Homo sapiens)
Participates
as an event of
Cation-coupled Chloride cotransporters (Homo sapiens)
Orthologous Events
SLC12A3 binds SLC12A3 inhibitors (Bos taurus)
SLC12A3 binds SLC12A3 inhibitors (Caenorhabditis elegans)
SLC12A3 binds SLC12A3 inhibitors (Canis familiaris)
SLC12A3 binds SLC12A3 inhibitors (Drosophila melanogaster)
SLC12A3 binds SLC12A3 inhibitors (Mus musculus)
SLC12A3 binds SLC12A3 inhibitors (Rattus norvegicus)
SLC12A3 binds SLC12A3 inhibitors (Sus scrofa)
SLC12A3 binds SLC12A3 inhibitors (Xenopus tropicalis)
Authored
Jassal, B (2021-03-25)
Reviewed
Huddart, R (2022-03-01)
Created
Jassal, B (2021-03-31)
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