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transit-amplifying cell of epidermis basal layer
Stable Identifier
R-HSA-9725625
Type
Cell
Species
Homo sapiens
Synonyms
keratinocyte of basal layer of epidermis, keratinocyte of skin epidermis stratum basale
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin (Homo sapiens)
Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis (Homo sapiens)
transit-amplifying cell of epidermis basal layer (Homo sapiens)
Transit-amplifying cell of basal layer differentiates into keratinocyte of spinosum layer in interfollicular epidermis (Homo sapiens)
transit-amplifying cell of epidermis basal layer (Homo sapiens)
Cytology
Organ
skin of body
(UBERON:0002097)
Tissue
skin epidermis
(UBERON:0001003)
Tissue Layer
stratum basale of epidermis
(UBERON:0002025)
Cell Type
keratinocyte
(CL:0000312)
Markers
Protein
AQP3 [plasma membrane]
(Homo sapiens)
Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3.
J Biol Chem
277,
17147-53
(2002)
Ma, T., Verkman, AS., Verbavatz, JM., Hara, M., Sougrat, R.
PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.
Database (Oxford)
2019,
null
(2019)
Franzén, O., Gan, LM., Björkegren, JLM.
Functional expression of AQP3 in human skin epidermis and reconstructed epidermis.
J Invest Dermatol
118,
678-85
(2002)
Gondran, C., Dumas, M., Gobin, R., Morand, M., Verbavatz, JM., Bonté, F., Barré, P., Sougrat, R.
Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes.
Biochim Biophys Acta
1522,
82-8
(2001)
Ota, Y., Sugiyama, Y., Inoue, S., Hara, M.
KRT14 [cytosol]
(Homo sapiens)
Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.
J Invest Dermatol
97,
959-68
(1991)
Chapman, SJ., Lane, EB., Leigh, IM., McGrath, JA., Ishida-Yamamoto, A., Eady, RA.
CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.
Nucleic Acids Res
null,
null
(2022)
Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
Keratinocyte Differentiation by Flow Cytometry.
Methods Mol Biol
2109,
83-92
(2020)
Sanz-Gómez, N., Gandarillas, A., Freije, A.
K15 expression implies lateral differentiation within stratified epithelial basal cells.
Lab Invest
80,
1701-10
(2000)
Ogden, PH., McLean, WH., Evans, A., Lunny, DP., Harrison, DL., Morley, SM., Lane, EB., Rugg, EL., Porter, RM.
PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.
Database (Oxford)
2019,
null
(2019)
Franzén, O., Gan, LM., Björkegren, JLM.
Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study.
Lancet
374,
1745-53
(2009)
Lemaitre, G., Del Rio, M., Saidani, M., Guenou, H., Baldeschi, C., Peschanski, M., Larcher, F., Waksman, G., Bernard, FX., Feteira, J., Nissan, X., Barrault, CC.
Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression.
Cell Tissue Res
363,
735-50
(2016)
Parry, DA., Schweizer, J., Kittstein, W., Langbein, L., Praetzel-Wunder, S., Eckhart, L., Fischer, H., Rogers, MA.
KRT5 [cytosol]
(Homo sapiens)
Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.
J Invest Dermatol
97,
959-68
(1991)
Chapman, SJ., Lane, EB., Leigh, IM., McGrath, JA., Ishida-Yamamoto, A., Eady, RA.
Delayed onset of epidermal differentiation in psoriasis.
J Invest Dermatol
98,
902-10
(1992)
Bernerd, F., Magnaldo, T., Darmon, M.
CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.
Nucleic Acids Res
null,
null
(2022)
Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
Keratinocyte Differentiation by Flow Cytometry.
Methods Mol Biol
2109,
83-92
(2020)
Sanz-Gómez, N., Gandarillas, A., Freije, A.
PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.
Database (Oxford)
2019,
null
(2019)
Franzén, O., Gan, LM., Björkegren, JLM.
Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study.
Lancet
374,
1745-53
(2009)
Lemaitre, G., Del Rio, M., Saidani, M., Guenou, H., Baldeschi, C., Peschanski, M., Larcher, F., Waksman, G., Bernard, FX., Feteira, J., Nissan, X., Barrault, CC.
Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression.
Cell Tissue Res
363,
735-50
(2016)
Parry, DA., Schweizer, J., Kittstein, W., Langbein, L., Praetzel-Wunder, S., Eckhart, L., Fischer, H., Rogers, MA.
KRT78 [cytosol]
(Homo sapiens)
Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression.
Cell Tissue Res
363,
735-50
(2016)
Parry, DA., Schweizer, J., Kittstein, W., Langbein, L., Praetzel-Wunder, S., Eckhart, L., Fischer, H., Rogers, MA.
ITGA6(24-1130) [plasma membrane]
(Homo sapiens)
Enrichment for murine keratinocyte stem cells based on cell surface phenotype.
Proc Natl Acad Sci U S A
97,
10960-5
(2000)
Morris, RJ., Tani, H., Kaur, P.
CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.
Nucleic Acids Res
null,
null
(2022)
Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
Location and phenotype of human adult keratinocyte stem cells of the skin.
Differentiation
72,
387-95
(2004)
Li, A., Kaur, P., Webb, A.
KRT15 [cytosol]
(Homo sapiens)
K15 expression implies lateral differentiation within stratified epithelial basal cells.
Lab Invest
80,
1701-10
(2000)
Ogden, PH., McLean, WH., Evans, A., Lunny, DP., Harrison, DL., Morley, SM., Lane, EB., Rugg, EL., Porter, RM.
PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.
Database (Oxford)
2019,
null
(2019)
Franzén, O., Gan, LM., Björkegren, JLM.
TFRC(1-760) [plasma membrane]
(Homo sapiens)
Enrichment for murine keratinocyte stem cells based on cell surface phenotype.
Proc Natl Acad Sci U S A
97,
10960-5
(2000)
Morris, RJ., Tani, H., Kaur, P.
CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.
Nucleic Acids Res
null,
null
(2022)
Jiang, W., Li, T., Wang, P., Li, F., Zhang, X., Chen, J., Li, X., Xu, Y., Ou, Q., Hu, C., Zhang, Y., Bai, J., Yang, K.
Location and phenotype of human adult keratinocyte stem cells of the skin.
Differentiation
72,
387-95
(2004)
Li, A., Kaur, P., Webb, A.
Participates
as an input of
Transit-amplifying cell of basal layer differentiates into keratinocyte of spinosum layer in interfollicular epidermis (Homo sapiens)
as an output of
Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis (Homo sapiens)
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