MYC/MYCN bind the ALK gene

Stable Identifier
Reaction [binding]
Homo sapiens
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MYC and MYCN bind to E boxes in the ALK promoter region to drive ALK gene expression as assessed by chromatin immunoprecipitation and reporter gene assays (Hasan et al, 2013). In turn, other studies have identified MYCN as a target of activated ALK in neuroblastoma, suggesting the ALK and MYCN may cooperate in driving progression of this disease (Schonherr et al, 2012; De Brouwer et al, 2010; Montavon et al, 2014; reviewed in Hallberg and Palmer, 2013)

Literature References
PubMed ID Title Journal Year
24356251 ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma

Nafady, A, Ohira, M, Nakamura, Y, Akter, J, Hossain, S, Hasan, MK, Ogura, A, Takatori, A, Nakagawara, A, Kadomatsu, K, Suenaga, Y, Kishida, S

Sci Rep 2013
24947326 Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

Sommer, L, Delattre, O, Jauquier, N, Coulon, A, Peuchmaur, M, Bourloud, KB, Flahaut, M, Yan, P, Mühlethaler-Mottet, A, Janoueix-Lerosey, I, Joseph, JM, Montavon, G, Gross, N

Oncotarget 2014
20719933 Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

Laureys, G, Cools, J, Eggert, A, Caron, H, Renard, M, Lakeman, A, Porcu, M, Van Maerken, T, De Brouwer, S, Westerhout, EM, Schulte, JH, Janoueix-Lerosey, I, Vandesompele, J, Ohira, M, Speleman, F, De Preter, K, Vermeulen, J, Versteeg, R, Zabrocki, P, Kumps, C, Nakagawara, A, Hoebeeck, J, Van Roy, N, Schramm, A, Noguera, R, Beiske, K, Delattre, O, De Paepe, A, Kogner, P, Martinsson, T, Van den Broecke, C

Clin Cancer Res 2010
22286764 Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells

Wang, CL, Hallberg, B, Kamaraj, S, Martinsson, T, Palmer, RH, Yang, HL, Ruuth, K, Combaret, V, Christensen, JG, Schönherr, C, Djos, A

Oncogene 2012
24060861 Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

Palmer, RH, Hallberg, B

Nat. Rev. Cancer 2013
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