IgE binds FCERI

Stable Identifier
R-HSA-9725206
Type
Reaction
Species
Homo sapiens
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Immunoglobulin-E (IgE)-mediated allergic responses require the binding of the IgE antibody to its high-affinity receptor, Fc epsilonRI (FCERI). Binding of one receptor blocks the binding of a second receptor. After this antigens can bind and crosslink IgE molecules held at the cell surface by FCERI (Garman et al. 2000).

Literature References
PubMed ID Title Journal Year
10917520 Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha

Kinet, JP, Tarchevskaya, SS, Jardetzky, TS, Garman, SC, Wurzburg, BA

Nature 2000
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