Immunoglobulin-E (IgE)-mediated allergic responses require the binding of the IgE antibody to its high-affinity receptor, Fc epsilonRI (FCERI). Binding of one receptor blocks the binding of a second receptor. After this antigens can bind and crosslink IgE molecules held at the cell surface by FCERI (Garman et al. 2000).
Kinet, JP, Tarchevskaya, SS, Jardetzky, TS, Garman, SC, Wurzburg, BA
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