PLG(20-810) binds anti-fibrinolytics

Stable Identifier
R-HSA-9724753
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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The plasminogen inhibitors aminocaproic acid (Sun et al. 2002) and tranexamic acid (Sperzel & Huetter 2007, Cheng et al. 2014) can be administered to patients undergoing coronary artery bypass graft surgery to reduce bleeding.
Literature References
PubMed ID Title Journal Year
24900876 Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction

Cheng, L, Pettersen, D, Ohlsson, B, Schell, P, Karle, M, Evertsson, E, Pahlén, S, Jonforsen, M, Plowright, AT, Boström, J, Fex, T, Thelin, A, Hilgendorf, C, Xue, Y, Wahlund, G, Lindberg, W, Larsson, LO, Gustafsson, D

ACS Med Chem Lett 2014
12007600 The blockage of the high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation

Sun, Z, Chen, YH, Wang, P, Zhang, J, Gurewich, V, Zhang, P, Liu, JN

Biochim Biophys Acta 2002
17666018 Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation

Sperzel, M, Huetter, J

J. Thromb. Haemost. 2007
Participants
Participates
Orthologous Events
Authored
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