GNRHR2 binds GNRH1,2

Stable Identifier
R-HSA-9724290
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Gonadotropin-releasing hormone receptor 1 can bind GNRH ligands
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Luteinizing hormone releasing hormone (LHRH, also termed gonadotropin releasing hormone GNRH), is a decapeptide involved in the control of human reproduction. There are two genes, LHRH I and II which encode two hormones (Seeburg & Adelman 1984, White et al. 1998). They are produced by hypothalamic neurones and mediates the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from gonadotropic cells in the anterior pituitary. Their effects are mediated by binding to the gonadotropin-releasing hormone receptor 2 (GNRHR2) (Faurholm et al. 2001) which couples with the G protein alpha-q/11 subunit.

Literature References
PubMed ID Title Journal Year
6090951 Characterization of cDNA for precursor of human luteinizing hormone releasing hormone

Adelman, JP, Seeburg, PH

Nature 1984
9419371 Second gene for gonadotropin-releasing hormone in humans

Eisen, JA, White, RB, Kasten, TL, Fernald, RD

Proc Natl Acad Sci U S A 1998
11707068 The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci

Millar, RP, Faurholm, B, Katz, AA

Genomics 2001
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